Case-based review explores brain-gut axis interventions for fatigue in Long COVID and ME/CFS, suggesting the need for further studies.
Brain-gut axis-based interventions may alleviate fatigue in ME/CFS and Long COVID by potentially modulating neuroinflammation, restoring microbiome balance, and improving epithelial barrier function. EA-based vagal stimulation represents a feasible option for patients with severe or treatment-resistant symptoms. Larger mechanistic studies and rigorously designed RCTs are needed to establish therapeutic targets and optimize intervention strategies.
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Kim et al. (2026) studied this question.
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