Genomic analysis of the genetic background underlying Streptococcus pneumoniae beta-lactam nonsusceptibility in central Vietnam: increased beta-lactam nonsusceptibility and dynamics of the pbp2x gene

Key Points

• The study aims to investigate the genetic factors contributing to beta-lactam nonsusceptibility in Streptococcus pneumoniae isolates in central Vietnam.
• Conducted genomic analysis of Streptococcus pneumoniae isolates from central Vietnam.
• Analyzed the dynamics of the pbp2x gene in relation to beta-lactam nonsusceptibility.
• Evaluated the effect of pbp2x alleles on clinical outcomes.
• Found widespread beta-lactam nonsusceptibility among Streptococcus pneumoniae isolates.
• Identified the pbp2x gene dynamics as a primary driver of nonsusceptibility.
• Observed that the nonsusceptible pbp2x allele had minimal impact on clinical outcomes.