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February 13, 2026Respiratory Research0 citationsOpen Access

Hypoxia-preconditioned mesenchymal stromal cell–derived exosomes attenuate LPS-induced acute lung injury and early epithelial remodeling in mice: evidence for a miR-486a-5p–Skp2–GATA4 axis

QLQun LinSZSiling ZouCLCan Lin

Key Points

  • The aim is to investigate the protective effects of hypoxia-preconditioned BMSC-derived exosomes on acute lung injury caused by LPS.
  • Utilized hypoxia-preconditioned bone marrow-derived mesenchymal stromal cell exosomes
  • Induced acute lung injury in mice using LPS
  • Analyzed the role of miR-486a-5p/Skp2/GATA4 axis
  • Exosomes significantly reduced LPS-induced acute lung injury
  • Decreased early epithelial remodeling observed
  • Validated the involvement of the miR-486a-5p/Skp2/GATA4 axis in the therapeutic effect

Abstract

Hypoxia-preconditioned bone marrow-derived mesenchymal stromal cell (BMSC) exosomes demonstrate significant potential to alleviate LPS-induced acute injury and early epithelial remodeling by engaging a miR-486a-5p/Skp2/GATA4 working model, offering a proof-of-concept therapeutic strategy for ALI.

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Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/698ebedd85a1ff6a93016203https://doi.org/10.1186/s12931-026-03560-2
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