Single-cell transcriptome analysis identifies keratinocyte activation as a driver of inflammation in atopic dermatitis, suggesting new therapeutic strategies.
Our results suggest that the persistent activation of antigen processing and presentation pathways in keratinocytes may be a key driver of chronic inflammation in AD. Therefore, redirecting anti-allergic therapeutic strategies from solely targeting immune cells to targeting of keratinocyte-mediated antigen presentation may offer a more effective approach. Furthermore, we raise concerns about the use of ovalbumin-induced mouse models to recapitulate human chronic AD, as the underlying mechanisms may differ significantly.
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Liu et al. (2026) studied this question.
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