Increased Gut Microbiota Diversity in Patients With Retinitis Pigmentosa and Implications for Disease Phenotypes and Progression

Jessica Bagel; Sachiko Iwai; Hanako Ohashi Ikeda; Daichi Miyaoka; Noriaki Sato; Kosuke Fujimoto; Xinyi Wei; Mami Kusaka; Manabu Miyata; Shogo Numa; Yuki Otsuka; Seiya Imoto; Satoshi Uematsu; Akitaka Tsujikawa

doi:10.1167/iovs.67.2.27

February 11, 2026Investigative Ophthalmology & Visual ScienceOpen Access

Increased Gut Microbiota Diversity in Patients With Retinitis Pigmentosa and Implications for Disease Phenotypes and Progression

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Key Points

The study aims to explore the differences in gut microbiota between patients with retinitis pigmentosa and healthy individuals, and how these differences relate to disease progression.
Compared gut microbiota of patients with retinitis pigmentosa and healthy individuals.
Used a model mouse to assess the impact of antibiotic treatment on disease progression.
Investigated potential therapeutic strategies targeting gut microbiota.
Distinct gut microbiota profiles were identified in patients with retinitis pigmentosa compared to healthy individuals.
Antibiotic treatment slowed disease progression in the retinitis pigmentosa model mouse.
Targeting gut microbiota could be a potential strategy for managing retinitis pigmentosa.

Implication

Research reveals that altering gut microbiota may slow disease progression in retinitis pigmentosa, suggesting new treatment avenues.

Abstract

Patients with RP exhibited distinct gut microbiota characteristics compared to that of healthy individuals. Treatment with antibiotics attenuated disease progression in the RP model mouse. Modifying the gut microbiota may be a potential therapeutic strategy for modifying disease progression in RP in future investigations.

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Cite This Study

Bagel et al. (2026) studied this question.

synapsesocial.com/papers/698ebf3485a1ff6a93016594 https://doi.org/10.1167/iovs.67.2.27

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Increased Gut Microbiota Diversity in Patients With Retinitis Pigmentosa and Implications for Disease Phenotypes and Progression

Key Points

Implication

Abstract

Discussion

Cite This Study

Increased Gut Microbiota Diversity in Patients With Retinitis Pigmentosa and Implications for Disease Phenotypes and Progression

Key Points

Implication

Abstract

Discussion

Cite This Study

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