Inflammatory cytokine profile in pregnant women colonized with group B streptococcus reveals IL-17A as a potential biomarker to identify at-risk newborns.

Narjis Amar; A. Chakroun; Hanane Ben-Taleb; Hind Sebbah; Naima Samouh; A. Badre; N. Habti; Hanane Salih-Alj; R. Saile; Mustapha Chamekh

doi:10.1093/infdis/jiag092

February 11, 2026

Inflammatory cytokine profile in pregnant women colonized with group B streptococcus reveals IL-17A as a potential biomarker to identify at-risk newborns.

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Key Points

The research aims to identify inflammatory cytokines related to group B streptococcus colonization in pregnant women and their implications for newborns.
Comparison of cytokine profiles between GBS-colonized and non-colonized mothers.
Assessment of maternal IL-17A levels in relation to newborn GBS risk.
Analysis of mother-newborn dyads to evaluate disease transmission dynamics.
GBS-colonized mothers exhibit a higher inflammatory cytokine response.
Maternal IL-17A levels correlate with increased risk of GBS transmission to newborns.
IL-17A is identified as a significant biomarker for predicting neonatal invasive disease.

Implication

Shows maternal IL-17A predicts GBS transmission risk in newborns, indicating potential interventions.

Abstract

This study shows that GBS-colonized-mothers may exhibit a greater cytokine inflammatory response compared to non-colonized-mothers. Regarding mother-newborn dyads, maternal IL-17A, a key mediator of antibacterial defense, emerges as a significant prognostic biomarker for assessing the risk of GBS transmission and the development of neonatal GBS invasive disease.

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Cite This Study

Amar et al. (2026) studied this question.

synapsesocial.com/papers/698ebf5085a1ff6a930169b6 https://doi.org/10.1093/infdis/jiag092

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Inflammatory cytokine profile in pregnant women colonized with group B streptococcus reveals IL-17A as a potential biomarker to identify at-risk newborns.

Key Points

Implication

Abstract

Discussion

Cite This Study

Inflammatory cytokine profile in pregnant women colonized with group B streptococcus reveals IL-17A as a potential biomarker to identify at-risk newborns.

Key Points

Implication

Abstract

Discussion

Cite This Study

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