Phenotypic age acceleration and early-onset lung cancer: a case–control and prognostic cohort study involving multiple clinical centres with validation in the UK Biobank

Key Points

• This research investigates the relationship between phenotypic age acceleration and the incidence of early-onset lung cancer.
• Conducted a case-control study involving multiple clinical centres
• Involved a prognostic cohort analysis
• Utilized clinical data for validation in the UK Biobank
• Identified significant correlation between phenotypic age acceleration and early lung cancer onset
• Demonstrated that faster aging traits could serve as potential biomarkers for lung cancer risk