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February 14, 2026European Urology0 citationsOpen Access

FORMULA-509: A Multicenter Randomized Trial of Postprostatectomy Salvage Radiotherapy and 6 months of a GNRH Agonist with Either Bicalutamide or Abiraterone Acetate plus Prednisone and Apalutamide

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PNPaul L. NguyenMKMarisa A. KollmeierDRDana E. Rathkopf

Key Points

  • The trial aims to evaluate the efficacy of various hormonal treatments combined with salvage radiotherapy after prostate surgery.
  • Conducted as a multicenter randomized trial
  • Participants received salvage radiotherapy and a GnRH agonist
  • Comparative analysis of bicalutamide versus abiraterone acetate plus prednisone and apalutamide
  • Subgroup analysis for patients with PSA levels greater than 0.5 ng/ml
  • No overall benefit was observed in the entire population
  • Addition of abiraterone acetate plus apalutamide significantly improved progression-free survival in the subgroup
  • Metastasis-free survival also improved in the subgroup with elevated PSA levels

Abstract

This study did not reveal a benefit for the overall population, but addition of AAP + apalutamide (vs bicalutamide) to sRT and ADT improved PFS and MFS in the prespecified subgroup with PSA >0.5 ng/ml.

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Cite This Study

Nguyen et al. (2026) studied this question.

synapsesocial.com/papers/699010382ccff479cfe56bbehttps://doi.org/10.1016/j.eururo.2025.12.001
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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer2017 · 674 citations
  2. 2LBA64 Duration of androgen suppression with post-operative radiotherapy (DADSPORT): A collaborative meta-analysis of aggregate data2022 · 30 citations
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  5. 5The Long-Term Clinical Impact of Biochemical Recurrence of Prostate Cancer 5 or More Years After Radical Prostatectomy2003 · 243 citations