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February 14, 2026Systematic ReviewsOpen Access

Effects of exercise training among adults with multiple sclerosis: protocol for a systematic review that informs an updated prescriptive guideline

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Authors

LDLouise DeclerckKGKathleen Martin GinisACAmy Cheung

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Overview

This systematic review evaluates exercise training outcomes in adults with multiple sclerosis, suggesting an updated guideline for practice.

Key Points

  • To assess the necessary type and dose of exercise training for improving health outcomes in adults with multiple sclerosis.
  • Conducting a systematic review following PRISMA-P guidelines.
  • Including randomized controlled trials of chronic exercise interventions for MS.
  • Excluding studies focused on other neurological conditions or qualitative data.
  • Performing a comprehensive search across eight electronic databases.
  • Assessing methodological quality and risk of bias using TESTEX and RoB 2 tools.
  • Identifying the types of exercise that improve fitness and health biomarkers in individuals with MS.
  • Determining effects on physical and cognitive function, quality of life, and daily activity participation.

Cite This Study

Declerck et al. (2026) studied this question.

synapsesocial.com/papers/699010382ccff479cfe56bcehttps://doi.org/10.1186/s13643-026-03095-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multiple sclerosis: clinical aspects2018 · 619 citations
  2. 2Evidence-based scientific exercise guidelines for adults with spinal cord injury: an update and a new guideline2017 · 432 citations
  3. 3Safety of exercise training in multiple sclerosis: An updated systematic review and meta-analysis2023 · 47 citations
  4. 4A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications2020 · 90 citations
  5. 5The PRISMA 2020 statement: an updated guideline for reporting systematic reviews2021 · 13,997 citations