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February 14, 2026BMC Medicine0 citationsOpen Access

Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study

YZYutong ZhangLSLulu SunYZYing Zhao

Key Points

  • This study aims to examine the link between soluble tumor necrosis factor receptor 1 and cognitive decline, specifically in the context of tau pathology and brain atrophy.
  • Longitudinal design
  • Analysis of soluble TNFR1 levels
  • Assessment of cognitive decline
  • Evaluation of tau-related neurodegeneration
  • sTNFR1 shows association with cognitive decline
  • sTNFR1 correlates with tau-related neurodegeneration
  • Incremental predictive value is limited beyond established risk factors

Abstract

sTNFR1 is associated with cognitive decline and tau-related selective neurodegeneration, but provides limited incremental predictive value beyond established risk factors; external validation and replication are warranted.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/699010382ccff479cfe56c14https://doi.org/10.1186/s12916-026-04623-3
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