Bone morphogenetic protein receptor 2 signaling mediates mitochondrial Ca2+ transport through its regulation of TAK1 splice variant

These studies reveal that BMPR2 signaling regulates TAK1-d splice variant to mediate mitochondrial Ca²⁺ transport, which is dependent on the MCU. Our studies suggest that BMPR2 signaling utilizes mtCa²⁺ transport to regulate both mitochondrial bioenergetics and/or cell survival. Our studies provide novel insight into how aberrant BMPR2 signaling is pathogenic and suggests that the response could vary depending on the cell type.