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Experimental findings show Netrin-1 inhibits inflammation in asthma, suggesting it as a therapeutic target.
Netrin-1 exerts anti-inflammatory effect by inhibiting the NLRP3 inflammasome activation and suppressing HMGB1/RAGE/NF-κB signaling pathway activation. Our preliminary findings demonstrate that Netrin-1 may serve as a potential therapeutic target for asthma, offering novel insights into its pathogenic mechanisms.
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Zhou et al. (2026) studied this question.
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