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Preoperative lymphocyte signature predicts pancreatic fistula risk in patients undergoing surgery, implying better patient care.
In summary, preoperative circulating immune-cell composition can predict POPF in patients undergoing PD. The clinical application of the PFLS may enable the early identification of patients at high risk before pancreatic surgery, giving clinicians the opportunity to anticipate and mitigate POPF risk through tailored strategies in pre-, intra-, and post-operative settings.
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Garnier et al. (2026) studied this question.
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