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February 14, 2026Neurology0 citations

Previous Antiplatelet Therapy and Outcomes of Acute Ischemic Stroke With Large Vessel Occlusion Treated With Direct Endovascular Therapy

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ZBZeno BenciUniversità della Svizzera italianaGBGiovanni BiancoLaboratory for Biomedical NeurosciencesGDGiulio DisantoUniversità della Svizzera italiana

Key Result

Previous antiplatelet therapy is associated with better 90-day functional outcomes compared to no previous therapy in patients with anterior circulation LVO stroke treated with direct EVT.

Key Points

  • The research aims to evaluate the impact of previous antiplatelet therapy on outcomes in patients with acute ischemic stroke due to large vessel occlusion treated with direct endovascular therapy.
  • Class III evidence from observational data
  • Participants included patients with anterior circulation large vessel occlusion
  • Outcomes measured at 90 days post-direct endovascular therapy
  • Patients with previous antiplatelet therapy had better functional outcomes at 90 days
  • Comparison shows significant improvement over those without prior antiplatelet therapy

Structured PICO

Does previous antiplatelet therapy improve 90-day functional outcomes in patients with anterior circulation LVO stroke treated with direct EVT?

P
Population
Patients with anterior circulation large vessel occlusion (LVO) stroke treated with direct endovascular therapy (EVT)
I
Intervention
Previous antiplatelet therapy (APT)
C
Comparator
No previous antiplatelet therapy
O
Outcome
90-day functional outcomeshard clinical

Prior use of antiplatelet therapy is associated with improved 90-day functional recovery in patients undergoing direct endovascular therapy for anterior circulation large vessel occlusion stroke.

Abstract

This study provides Class III evidence that, in patients with anterior circulation LVO stroke treated with direct EVT, previous APT is associated with better 90-day functional outcomes compared with no previous APT.

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Cite This Study

Benci et al. (2026) studied this question. Previous antiplatelet therapy is associated with better 90-day functional outcomes compared to no previous therapy in patients with anterior circulation LVO stroke treated with direct EVT.

synapsesocial.com/papers/699010942ccff479cfe56f11https://doi.org/10.1212/wnl.0000000000214672
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