⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

February 12, 2026Annals of Laboratory MedicineOpen Access

Assessment of a High-resolution HPLC System to Quantify HbE for α ⁰ -Thalassemia Diagnosis in HbE Heterozygotes

Wibhasiri Srisuwan Surada Satthakarn Sitthichai Panyasai

View Full Paper

Ask AI

Bookmark

Share

Key Points

To evaluate the effectiveness of a high-resolution HPLC system in quantifying HbE for α<sup>0</sup>-thalassemia diagnosis.
Utilized a high-resolution HPLC system for HbE quantification
Conducted analysis specifically in HbE heterozygotes
Assessed diagnostic capability without evaluating HbA<sub>2</sub>
Demonstrated precise quantification of HbE levels
Proposed a robust method for α<sup>0</sup>-thalassemia diagnosis
Highlighted the utility of HPLC for screening purposes

Implication

Assessment of a high-resolution HPLC system quantifies HbE in heterozygotes, indicating its potential for reliable diagnosis.

Abstract

PR-HPLC can quantify HbE precisely, potentially aiding in robust α⁰-thalassemia diagnosis and screening without HbA₂ assessment.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Srisuwan et al. (2026) studied this question.

synapsesocial.com/papers/699010ce2ccff479cfe56f7a https://doi.org/10.3343/alm.2025.0552

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Performance Evaluation of a Premier Resolution <scp>HPLC</scp> System for Detecting Hemoglobin Constant Spring, Hemoglobin Paksé, and Coexisting α‐ and β‐Thalassemia MutationsEarly-Phase Clinical Trial · 2026
2Alpha-thalassaemia early eluting peak for alpha-thalassaemia --SEA carrier screening: a multicentre diagnostic comparison with immunochromatographic strip test and haemoglobin H inclusion testOriginal Research · 2026
3Diagnosis of Hemoglobinopathies and thalassemias using both Haemoglobin capillary zone electrophoresis and High performance liquid chromatography - An experience from a tertiary care hospital in Northern India2024
4HPLC in the characterization of hemoglobin profile in thalassemia syndrome in a tertiary care hospitalOriginal Research · 2026
5A Study on the Incidence of Abnormal Haemoglobin in a Quaternary Care Setup Along with the Estimation of Their Retention Time by HPLCCohort Study · 2026

More related papers

The Efficiency of Capillarys 2 Flex Piercing, Premier Resolution-HPLC, and VARIANT II-HPLC for Hemoglobin Constant Spring Detection2026
Discrepancies in hemoglobin A2 measurement between capillary electrophoresis and high-performance liquid chromatography in β-thalassemia trait2025
Comparison of High-Performance Liquid Chromatography and Capillary Electrophoresis in the Screening of Haemoglobinopathies2024

More from Annals of Laboratory Medicine

White Blood Cell Counting in Severely Leukopenic Samples on a Sysmex XN Hematology Analyzer: Analytical Performance Evaluation of Whole Blood Mode and Low White Blood Cell ModeFri,
Commutability Assessment of Materials for Serum Copper Measurement Using the IFCC Difference-in-Bias and the CLSI EP30 ApproachesWed,