PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 14, 2026RSC Medicinal ChemistryOpen Access

Synthesis and evaluation of 14β-acyl substituted 17cyclopropylmethyl-7,8-dihydromorphinone derivatives: mixed partial agonists at mu opioid and nociception/orphanin FQ peptide receptors

View Full Paper
Ask AI
Bookmark
Share

Authors

MOMehrnoosh OstovarUniversity of BathKOKeith OlsenUniversity of MichiganGCGerta Cami-KobeciUniversity of Bath

Discussion

Loading...

Member takes

Overview

Evaluation of mixed partial agonists at mu opioid and nociception receptors for pain management, suggesting new treatment options.

Key Points

  • This research aims to synthesize and evaluate new compounds that can manage severe pain with fewer side effects than traditional opioids.
  • Synthesize 14β-acyl substituted 17cyclopropylmethyl-7,8-dihydromorphinone derivatives.
  • Evaluate their activity as mixed partial agonists at mu opioid and nociception receptors.
  • Analyze their potential as analgesics in comparison to standard opioids.
  • Identified new derivatives with partial agonist properties at mu opioid receptors.
  • Showed reduced adverse effects compared to traditional opioids.
  • Suggested potential as effective treatments for chronic pain management.

Cite This Study

Ostovar et al. (2026) studied this question.

synapsesocial.com/papers/699010ce2ccff479cfe570cbhttps://doi.org/10.1039/d5md00685f
View Full Paper
Ask AI
Bookmark
Share