Multifunctional Degradable Highly Branched-linear Poly (β-amino esters) for Efficient YAP Gene Delivery

Key Points

• Investigate effective delivery systems for the YAP gene and their implications in cancer and tissue repair.
• Developed multifunctional poly(beta-amino esters) for gene delivery.
• Assessed safety and efficiency in cellular models.
• Evaluated gene expression regulation related to YAP in cancer and tissue repair contexts.
• Demonstrated improved delivery efficiency of YAP gene using the developed polymers.
• Showed potential for enhancing skin tissue repair processes.
• Indicated a reduction in cancer cell proliferation linked to YAP modulation.