Multifunctional Degradable Highly Branched-linear Poly (β-amino esters) for Efficient YAP Gene Delivery

Chenfei Wang; Linjing Shi; Sen Luo; Zhuo Huang; Weiyi Xu; Hui Ling Li

doi:10.1039/d5bm01543j

January 1, 2026Biomaterials Science

Multifunctional Degradable Highly Branched-linear Poly (β-amino esters) for Efficient YAP Gene Delivery

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Key Points

Investigate effective delivery systems for the YAP gene and their implications in cancer and tissue repair.
Developed multifunctional poly(beta-amino esters) for gene delivery.
Assessed safety and efficiency in cellular models.
Evaluated gene expression regulation related to YAP in cancer and tissue repair contexts.
Demonstrated improved delivery efficiency of YAP gene using the developed polymers.
Showed potential for enhancing skin tissue repair processes.
Indicated a reduction in cancer cell proliferation linked to YAP modulation.

Implication

This research explores efficient YAP gene delivery systems in cancer and skin tissue repair, highlighting potential benefits.

Abstract

Manipulation of the Yes-associated protein (YAP) gene offers considerable potential for elucidating cancer pathogenesis and promoting skin tissue repair. However, the development of safe and efficient YAP gene delivery systems...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/699010ce2ccff479cfe5714d https://doi.org/10.1039/d5bm01543j

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Multifunctional Degradable Highly Branched-linear Poly (β-amino esters) for Efficient YAP Gene Delivery

Key Points

Implication

Abstract

Discussion

Cite This Study

Multifunctional Degradable Highly Branched-linear Poly (β-amino esters) for Efficient YAP Gene Delivery

Key Points

Implication

Abstract

Discussion

Cite This Study

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