Demonstrates the construction of a brain spatial transcriptomic atlas, highlighting its implications for precision medicine in neuropsychiatric disorders.
The emergence of spatial genomics has introduced new possibilities to studying structure-function relationships in neuropsychiatric disorders. Spatial transcriptomics (ST) allows the detection of thousands of genes simultaneously up to single-cell resolution which holds spatial location of gene transcriptional activity within a tissue sample. Spatial genomics technologies are developed rapidly, and many of them were used for constructing brain spatial genomics atlases. A brain spatial transcriptomic atlas is a map of the gene expression across brain regions in situ—that is, within their anatomical context—often at single-cell or near-single-cell resolution. The brain spatial genomics atlas has been constructed for a few species including mice and humans. These brain atlases can be used to further investigate specific genes or pathways that are dysregulated in disease, advancing therapeutic development as a result. The spatial genomics and brain ST atlas are vital for driving precision medicine efforts for neurological disorders.
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Xiong et al. (2026) studied this question.
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