Single-cell dissection of plasma cell clonal evolution to smoldering multiple myeloma after CD19 CAR-T cell therapy in B-cell acute lymphoblastic leukemia

Key Points

• To investigate how plasma cell clones evolve into smoldering multiple myeloma after CD19 CAR-T therapy in B-cell acute lymphoblastic leukemia.
• Performed single-cell sequencing of plasma cells
• Analyzed clonal evolution patterns
• Assessed responses to CAR-T cell therapy
• Identified specific plasma cell clones associated with myeloma development
• Noted alterations in clonal diversity post-therapy
• Observed correlations between clonal changes and therapeutic responses