This work demonstrates direct C-H fluorination in hydrazones, suggesting a simple electrochemical method could enable diverse products.
In this work, we present a mild and efficient electrochemical method for the direct C-H fluorination of aldehyde hydrazones using KF as an inexpensive and readily available fluorine source. This direct electrochemical approach could tolerate various functional groups, affording a diverse collection of (Z)-fluorinated hydrazones. Cyclic voltammetry and associated mechanistic investigations were conducted to provide insight into the radical mechanistic pathway.
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Sarkar et al. (2026) studied this question.
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