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February 16, 20260 citationsOpen Access

A Rare Cause of Life-Threatening Chest Pain: Kounis Syndrome

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LJLiangliang JiaYLYabin LiuXCXi Chen

Key Points

  • The aim is to emphasize the significance of early diagnosis and intervention in Kounis syndrome.
  • Case report detailing a 50-year-old female patient with recurrent chest pain and allergic comorbidities.
  • Diagnosis of type I Kounis syndrome based on clinical presentation and hypereosinophilia.
  • Treatment modifications included diltiazem and prednisolone.
  • Treatment led to complete resolution of symptoms.
  • Highlights the critical importance of recognizing Kounis syndrome early to prevent fatal outcomes.

Abstract

Kounis syndrome, defined as an acute coronary syndrome triggered by allergic or hypersensitivity reactions, is a rare yet potentially life-threatening condition. This report details the case of a 50-year-old female patient presenting with recurrent chest pain, hypereosinophilia, and allergic comorbidities, who was ultimately diagnosed with type I Kounis syndrome. Modifications to her treatment regimen, including the administration of diltiazem and prednisolone, led to a complete resolution of her symptoms. This case highlights the critical importance of early diagnosis and timely intervention in managing Kounis syndrome. Early recognition is essential to prevent potentially fatal outcomes, thereby emphasizing the need for increased awareness among healthcare professionals.

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Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/69926503eb1f82dc367a0d8ehttps://doi.org/10.3390/jcdd13020094
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