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This is a Literature Review study.

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This review aims to identify biases in single-cell RNA sequencing and evaluate targeted sequencing methods.

February 16, 2026Communications BiologyOpen Access

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This review aims to identify biases in single-cell RNA sequencing and evaluate targeted sequencing methods.
Review of biases in existing single-cell RNA sequencing protocols.
Classification of targeted sequencing solutions into five categories based on protocol steps.
Development of a decision tree for method selection.
Identified that current methods only detect 10–40% of total RNAs.
Discussed limitations in high-throughput methods regarding untranslated regions.
Provided a structured approach for researchers to choose suitable targeted methods.

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Review highlights biases in high-throughput methods and presents a decision tree for targeted RNA sequencing.

Moro et al. (2026) studied this question.

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