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February 16, 2026Open Access

Formulation and Evaluation of Doxophyline Sustained Release Tablets Using Different Polymers

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Authors

VVV. VithyaDKDr. V. KalvimoorthiLGL. Gopi

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Overview

Formulation shows improved therapeutic efficacy in delivering doxophylline, indicating better patient compliance with sustained release.

Key Points

  • To formulate and evaluate sustained-release tablets of doxophylline with various polymers.
  • Prepared two formulations using different methods: F1 (direct compression) and F2 (wet granulation).
  • Included doxophylline, microcrystalline cellulose, and hydroxypropyl methylcellulose with additives like talc and magnesium stearate.
  • Conducted preformulation studies assessing physicochemical properties such as solubility and compressibility.
  • Both formulations met pharmacopoeial standards for mechanical strength and drug release.
  • Granule evaluations showed excellent flow properties and good physical characteristics.
  • Sustained-release tablets effectively enhance therapeutic efficacy and patient compliance.

Cite This Study

Vithya et al. (2026) studied this question.

synapsesocial.com/papers/69926503eb1f82dc367a0e5ahttps://doi.org/10.5281/zenodo.18638943
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