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February 16, 2026International Journal of Neuroscience

The correlation between YTHDF1 gene polymorphism and cognitive dysfunction after radiotherapy for glioma

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Authors

HZHuanfeng ZhuXSXiyun ShiDZDan Zong

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Overview

Analysis shows gene polymorphism impacts cognitive dysfunction in glioma after radiotherapy, suggesting genetic markers could guide patient outcomes.

Key Points

  • This research examines the link between YTHDF1 gene polymorphism and cognitive dysfunction post-radiotherapy in glioma patients.
  • Cohort of glioma patients receiving radiotherapy was analyzed.
  • Assessment of cognitive function was performed after treatment.
  • Evaluation of YTHDF1 gene polymorphism was conducted, focusing on rs6090311 G allele.
  • YTHDF1 overexpression correlates with cognitive dysfunction in glioma patients post-radiotherapy.
  • The rs6090311 G allele may serve as a protective genetic marker against cognitive decline.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/69926503eb1f82dc367a0e82https://doi.org/10.1080/00207454.2026.2630961
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1YTHDF1 promotes the viability and self‑renewal of glioma stem cells by enhancing LINC00900 stability2024 · 4 citations
  2. 2Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after traumatic brain injury2024
  3. 3YTHDF2 promotes gastric cancer progression and enhances chemoradiotherapy resistance2024 · 4 citations
  4. 4YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production2024 · 28 citations
  5. 5YTHDF3 facilitates DNA damage response by recognizing METTL3-mediated m6A modification to promote chemotherapy resistance in glioblastoma2026 · 2 citations