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February 16, 20260 citationsOpen Access

Distinct Neurophysiological Signatures of Propofol and Ketamine Anesthesia: A Test of Dissociable Mechanisms of Consciousness Loss

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CTC.S. Thomas

Key Points

  • To compare neurophysiological signatures associated with consciousness loss due to propofol and ketamine anesthesia.
  • Pre-registered analysis plan for a prospective within-subjects study.
  • Comparison of neurophysiological signatures under two anesthetic agents.
  • Focus on TMS-EEG capabilities and target-controlled infusion infrastructure.
  • Identification of distinct neurophysiological signatures for propofol and ketamine anesthesia.
  • Evidence suggesting dissociable mechanisms involved in consciousness loss.

Abstract

This document specifies a pre-registered analysis plan for a prospective within-subjects study comparing dissociable mechanisms of consciousness loss under two common anesthetic agents, propofol and ketamine. It is intended as a collaborative proposal for anesthesia research groups with TMS-EEG capability and target-controlled infusion infrastructure.

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Cite This Study

C.S. Thomas (2026) studied this question.

synapsesocial.com/papers/69926552eb1f82dc367a1317https://doi.org/10.5281/zenodo.18642715
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