Prospective analysis compares propofol and ketamine anesthesia, revealing dissociable consciousness loss mechanisms.
This document specifies a pre-registered analysis plan for a prospective within-subjects study comparing dissociable mechanisms of consciousness loss under two common anesthetic agents, propofol and ketamine. It is intended as a collaborative proposal for anesthesia research groups with TMS-EEG capability and target-controlled infusion infrastructure.
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C.S. Thomas (2026) studied this question.
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