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Novel cell-free therapy reduces bone resorption in apical periodontitis, suggesting new treatments in regenerative endodontics.
This study developed a novel cell-free therapeutic strategy based on SHED-EXOs to enhance the treatment efficacy for AP. SHED-EXOs effectively inhibit osteoclast activity, attenuate bone resorption, and promote periapical bone tissue repair. The underlying mechanism involves the activation of the PI3K-AKT pathway. Combined with a localized hydrogel delivery system, this strategy paves the way for innovative approaches in regenerative endodontics.
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Wang et al. (2026) studied this question.
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