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Comparative genomic analyses reveal gene loss mechanisms in squamates, suggesting new pharmaceutical approaches for immune modulation.
Together, our comparative genomic analyses highlight that the loss of crucial genes in squamate lineages has occurred primarily through inter- and intrachromosomal rearrangements, including segmental deletions. These findings offer insights into the evolutionary loss of genes involved in macrophage differentiation and inform the development of novel pharmaceutical approaches for modulating immune responses.
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Salve et al. (2026) studied this question.
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