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Integrated approach tests dual inhibition of quorum sensing and efflux pumps in ESKAPE pathogens, suggesting new treatments.
An integrated computational and experimental approach validated five (5) sulphamethoxazole derivatives targeting dihydropteroate synthase (DHPS) protein as dual inhibitors of quorum sensing (LasR) and efflux pumps (AcrB) with SMX033 as the best hit.
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Adzah et al. (2026) studied this question.
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