Normalizing Uricemia in Psoriatic Arthritis: A Hypothetical Reduction of Atherosclerotic Plaque Burden

Key Points

• This research aims to explore the relationship between hyperuricemia and atherosclerotic plaque burden in psoriatic arthritis.
• Theoretical analysis based on existing evidence of hyperuricemia's role in cardiovascular disease and psoriatic inflammation.
• Review of mechanisms including interleukin pathways and endothelial activation in atherosclerosis.
• Assessment of oxidative stress and neutrophil extracellular trap formation in psoriatic patients.
• Hyperuricemia is linked to increased atherosclerotic plaque burden due to inflammatory processes.
• Key inflammatory mediators such as IL-23 and TNF are involved in exacerbating endothelial activation.
• Findings imply that managing uricemia could potentially reduce cardiovascular risk in psoriatic arthritis.