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February 17, 2026Organic Letters

Markovnikov-Selective Hydroboration of Unactivated Alkenes via MHAT under Cobalt/Photoredox Dual Catalysis

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Authors

YSYusuke SeinoSDShintaro DozenTYTatsuhiko Yoshino

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Overview

Catalytic hydroboration shows selective formation of alkyl boronic esters in unactivated alkenes, suggesting new synthetic pathways.

Key Points

  • To develop a method for Markovnikov-selective hydroboration of unactivated alkenes using dual catalysis.
  • Employ Markovnikov-selective hydroboration using MHAT
  • Utilize cobalt and photoredox dual catalysis
  • Investigate the reaction across mono-, di-, and trisubstituted alkenes
  • Achieve high regioselectivity in hydroboration
  • Generate alkyl boronic esters from unactivated alkenes
  • Utilize radical intermediates to facilitate the reaction

Cite This Study

Seino et al. (2026) studied this question.

synapsesocial.com/papers/699405bb4e9c9e835dfd692ehttps://doi.org/10.1021/acs.orglett.6c00348
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