Late Outcomes of Permanent Pacemaker Implantation After TAVR: Meta-analysis of Reconstructed Time-to-Event Data

Figures

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  Figure 1. Flow diagram of studies included in data search. A total of 4008 records were identified, 70 full-text articles were assessed for eligibility, and 28 articles were included in the study. KM, Kaplan-Meier; TAVR, transcatheter aortic valve replacement.

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  Figure 2. Risk of bias summary. The Risk of Bias in Non-Randomized Studies of Interventions tool with (A) traffic lights and (B) summary plots.

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  Figure 3. Pooled Kaplan-Meier curves showing the cumulative risk of all-cause mortality, rehospitalization, stroke, and endocarditis after transcatheter aortic valve replacement with and without PPI. (A and B) Shows the impact of PPI on mortality and rehospitalization, whereas (C and D) does not show any statistically significant differences. HR, hazard ratio; PPI, permanent pacemaker implantation.

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  Figure 4. Sensitivity analysis (1-study-removed analysis). (A-C) All Kaplan-Meier curves shows the consistent impact of PPI on mortality and rehospitalization despite the removal of some studies from the analyses. HR, hazard ratio; PPI, permanent pacemaker implantation.

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  Central Illustration. Impact of permanent pacemaker implantation after transcatheter aortic valve implantation. HF, heart failure; HR, hazard ratio; PPI, permanent pacemaker implantation; TAVR, transcatheter aortic valve replacement.

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  Supplementary Figure 1.

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  Supplementary Figure 2.