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February 19, 2026Advanced Functional Materials0 citationsOpen Access

Scaffold Hopping Enhances NIR‐II AIE Sensing for In Vivo Imaging

Scaffold Hopping Generates NIR‐II AIE Platform for In Vivo Imaging and Activity‐Based Sensing

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Authors

HSHanchen ShenBYBaofeng YunJZJianyu Zhang

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Overview

Demonstrates a new NIR‐II sensing platform enhancing fluorescence in vivo, suggesting a novel method for imaging and sensing.

Key Points

  • The research aims to develop a NIR‐II aggregation‐induced emission (AIE) platform for improved imaging and sensing in vivo.
  • Introduced dimethylamino groups for modifiable NIR‐II probes
  • Utilized scaffold hopping to enhance molecular properties
  • Conducted single‐crystal analysis and theoretical calculations
  • Achieved a four‐fold increase in photoluminescence quantum yield
  • Enabled clear in vivo vascular imaging
  • Developed pH‐responsive and ROS‐responsive probes
  • Demonstrated effectiveness in reflecting inflammation in vivo

Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/6996a768ecb39a600b3ed180https://doi.org/10.1002/adfm.202531803
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