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February 19, 2026Frontiers in Medicine0 citationsOpen Access

Prognostic Biomarkers of Systemic Inflammation in Neuroendocrine Neoplasms

Connecting systemic inflammation to prognosis in neuroendocrine neoplasms: a biomarker-based approach

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Authors

AIAndreea IlieșiuAGAncuța-Augustina Gheorghişan-GǎlǎțeanuDȚDana Antonia Țǎpoi

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Overview

Retrospective analysis connects inflammatory biomarkers with mortality in neuroendocrine neoplasms, suggesting improved risk assessment.

Key Points

  • This analysis aims to identify cost-effective biomarkers that correlate with prognosis in neuroendocrine neoplasms.
  • Conducted a retrospective analysis of 60 patients with neuroendocrine neoplasms
  • Analyzed blood counts to derive neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)
  • Used logistic regression models to evaluate prognostic significance in relation to demographic and clinical features.
  • 38.3% of patients died during follow-up
  • Low lymphocyte counts and elevated PLR, NLR, and SII were significant predictors of mortality
  • Advanced age, poorly differentiated NEC histology, and elevated SII were linked to increased mortality in multivariate analysis.

Cite This Study

Ilieșiu et al. (2026) studied this question.

synapsesocial.com/papers/6996a798ecb39a600b3ed726https://doi.org/10.3389/fmed.2026.1728726
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