Investigates new phthalocyanine compounds' effectiveness in enhancing oxygen production in sonophotodynamic therapy and inhibiting enzymes related to neurological disorders.
Key Points
The aim is to evaluate the potential of newly synthesized phthalocyanines in sonophotodynamic therapy and their inhibitory effects on specific enzymes.
Synthesis of sodium 6-(2,3-dicyanophenoxy)naphthalene-2-sulfonate and metallophthalocyanines
Investigation of singlet oxygen production under photochemical and sonophotochemical conditions
Evaluation of inhibitory effects on acetylcholinesterase and human carbonic anhydrase isoenzymes using K i values
Molecular docking to assess binding affinities of complexes for target enzymes.
Zinc(II) complex shows highest singlet oxygen production under both conditions.
Strong inhibition of acetylcholinesterase and human carbonic anhydrase isoenzymes with K i values indicating effectiveness compared to standard inhibitors.
Molecular docking shows high binding affinity of In(III)-Pc for acetylcholinesterase, while Ga(III)-Pc binds preferentially to carbonic anhydrases.