What does this research mean for the field?

Glanzmann thrombasthenia can present with severe upper gastrointestinal bleeding, which can be effectively managed with a combination of treatments including recombinant activated factor VII and antifibrinolytic agents. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore the presentation and management of upper gastrointestinal bleeding in patients with Glanzmann thrombasthenia.

February 19, 2026SHILAP Revista de lepidopterologíaOpen Access

Glanzmann thrombasthenia presenting with upper gastrointestinal bleeding: a case series and review of the literature

View Full Paper

Ask AI

Bookmark

Authors

FAFeras Al-FararjehUniversity of Jordan AAAlaa AlshormanMinistry of Health SHSalem Hyari

Discussion

Member takes

Implication

Case series reports severe upper gastrointestinal bleeding in Glanzmann thrombasthenia, suggesting the need for careful management strategies.

Key Points

This research aims to explore the presentation and management of upper gastrointestinal bleeding in patients with Glanzmann thrombasthenia.
Case series of six patients with type I GT and upper GI bleeding
Treatment included rFVIIa, tranexamic acid, endoscopic intervention, and supportive care
Genetic studies conducted for each patient
Endoscopic findings varied from normal mucosa to visible vessels, polyps, and arteriovenous malformations
All cases successfully managed with treatment
Link between certain ITGB3 variants and severe bleeding was suggested

Cite This Study

Al-Fararjeh et al. (2026) studied this question.

synapsesocial.com/papers/6996a7c3ecb39a600b3edbf3 https://doi.org/10.3389/fmed.2026.1762228

View Full Paper

Ask AI

Bookmark

Implication

Case series reports severe upper gastrointestinal bleeding in Glanzmann thrombasthenia, suggesting the need for careful management strategies.

Glanzmann thrombasthenia presenting with upper gastrointestinal bleeding: a case series and review of the literature

Discussion

Member takes

Implication

Key Points

Cite This Study

Glanzmann thrombasthenia presenting with upper gastrointestinal bleeding: a case series and review of the literature

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider