Colchicine–cinnamic acid hybrids with potent anticancer activities: synthesis, in vitro , and in vivo biological evaluations

Key Points

• The aim is to evaluate the anticancer effects of colchicine–cinnamic acid hybrids.
• Synthesis of colchicine–cinnamic acid hybrid B7
• In vitro biological evaluations of hybrid B7
• In vivo biological evaluations of hybrid B7
• Hybrid B7 shows potent antitumor activity in laboratory tests.
• Both in vitro and in vivo studies demonstrate significant effects.