Enhanced pathogen detection and gut microbiome alterations in pyogenic liver abscess: insights from next-generation sequencing

Key Points

• To explore how next-generation sequencing (NGS) enhances pathogen detection and to assess gut microbiome alterations in pyogenic liver abscess patients.
• Utilized next-generation sequencing to identify pathogens in patients with pyogenic liver abscess.
• Analyzed gut microbiota composition and diversity in these patients.
• NGS significantly improved the detection of anaerobes and mixed infections.
• Patients exhibited marked dysbiosis in their gut microbiota.
• Findings suggest that gut microbiome alterations may contribute to the disease process.