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February 19, 2026Journal of drug targeting

Pravastatin-Loaded Nanostructured Lipid Carriers: Formulation Optimization and In-Vivo Assessment for Antihyperlipidaemic Effect in Rats

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Authors

AMAnjali MoreAZAmeeduzzafar ZafarOAOmar Awad Alsaidan

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Overview

Formulation optimization reveals enhanced lipid profile improvement in hyperlipidemic rats, suggesting better management of the condition.

Key Points

  • The research aims to develop nanostructured lipid carriers for pravastatin to enhance its antihyperlipidemic effect.
  • Conducted preformulation research and optimized formulations using a factorial design
  • Prepared NLCs via high-shear homogenization and ultrasonication with surfactants
  • Evaluated size, zeta potential, entrapment efficiency, and release kinetics
  • Assessed in vivo antihyperlipidemic activity in hyperlipidemic rats
  • Optimum formulation (F4) had an entrapment efficiency of 98.35% and a zeta potential of -65.9 mV
  • Particles were 203.0 nm in size, showing spherical morphology in SEM images
  • Sustained in vitro drug release of 96.4% over 12 hours
  • In vivo studies showed significantly improved lipid profiles compared to marketed pravastatin tablets

Cite This Study

More et al. (2026) studied this question.

synapsesocial.com/papers/6996a818ecb39a600b3ee818https://doi.org/10.1080/1061186x.2026.2632863
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