What question did this study set out to answer?

To explore the use of therapeutic ultrasound for the remote activation of bioactive molecules, particularly for biomedical applications.

Remote Molecule Activation in Living Mice Triggered by Therapeutic Ultrasound

View Full Paper

Ask AI

Bookmark

Authors

Experimental methodology enables targeted molecule activation in living animals, implying breakthrough potential in noninvasive therapies.

To explore the use of therapeutic ultrasound for the remote activation of bioactive molecules, particularly for biomedical applications.
Utilized therapeutic ultrasound to trigger the deboronative hydroxylation reaction (dBus).
Conducted mechanistic studies to understand the role of hydroxyl radicals from acoustic cavitation.
Applied dBus in in vivo models with tumor-bearing mice to assess therapeutic effects.
Confirmed effective hydroxylation of boronic acid moieties into hydroxyl groups.
Achieved significant tumor growth inhibition in mice with no observed toxicity.
Demonstrated precision activation of various molecular types, including peptides and fluorophores.

Qin et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

View Full Paper

Ask AI

Bookmark

Authors

Experimental methodology enables targeted molecule activation in living animals, implying breakthrough potential in noninvasive therapies.

To explore the use of therapeutic ultrasound for the remote activation of bioactive molecules, particularly for biomedical applications.
Utilized therapeutic ultrasound to trigger the deboronative hydroxylation reaction (dBus).
Conducted mechanistic studies to understand the role of hydroxyl radicals from acoustic cavitation.
Applied dBus in in vivo models with tumor-bearing mice to assess therapeutic effects.
Confirmed effective hydroxylation of boronic acid moieties into hydroxyl groups.
Achieved significant tumor growth inhibition in mice with no observed toxicity.
Demonstrated precision activation of various molecular types, including peptides and fluorophores.

Qin et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark