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February 19, 2026Blood2 citations

Time of infusion does not significantly impact outcomes following CAR T-cell therapy in large B-cell lymphoma

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MDMark R. DowlingECEdward R. Scheffer CliffAJAnthony Cole Jeffrey

Key Points

  • To investigate whether the timing of CAR T-cell infusion affects patient outcomes in large B-cell lymphoma.
  • Conducted a retrospective analysis of 584 patients
  • Examined outcomes after CAR T-cell therapy across six Australian centres
  • Adjusted for confounding variables to assess the impact of infusion timing
  • Found no significant association between infusion timing and patient outcomes
  • Results indicate minimal influence of chronobiology on therapeutic effectiveness

Abstract

In this retrospective analysis of 584 patients who received CAR T-cell therapy for LBCL at six Australian centres we found no association between time of infusion and outcome, accounting for confounders, suggesting minimal clinical impact of chronobiology in this setting.

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Cite This Study

Dowling et al. (2026) studied this question.

synapsesocial.com/papers/6996a83eecb39a600b3eec97https://doi.org/10.1182/blood.2025032307
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