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February 19, 2026Open Forum Infectious DiseasesOpen Access

Recovery and Stability of Omadacycline 150-mg Crushed Tablets Dispersed in Food or Water and Administered via Nasogastric Tube

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Authors

CHChenlin HuRHRicky Huynh-PhanKRKevin M Rodriguez Robles

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Overview

A study assesses the stability of crushed omadacycline dispersal methods, indicating optimal recovery methods for patients with swallowing difficulties.

Key Points

  • To assess the stability and recovery of crushed omadacycline 150-mg tablets when administered via nasogastric tube.
  • Evaluated recovery using 3 crushing methods (pill crusher, mortar/pestle, sandwich bag)
  • Tested dispersal in 3 products (water, vanilla syrup, applesauce)
  • Performed liquid chromatography tandem mass spectrometry to measure concentrations
  • No significant difference in recovery based on crushing method
  • Higher proportions of OMC-4-epimer found in applesauce compared to water or vanilla syrup
  • Recovery of omadacycline above 91% using nasogastric tube with optimal procedures

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/6996a84cecb39a600b3eee0chttps://doi.org/10.1093/ofid/ofag011
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