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February 19, 2026Organic Chemistry Frontiers0 citations

Diastereoselective Synthesis of Dioxaadamantane Skeletons from Coumarin-Fused Bridged Ketones via Triple Grignard Addition and Hydroalkoxylation Sequence

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HYHaoran YangNanjing Tech UniversityJLJiawei LiuNanjing Tech UniversityCYChangmeng YangNanjing Tech University

Key Points

  • The aim is to develop an efficient synthetic method for dioxaadamantane skeletons using a specific chemical process.
  • Utilized a diastereoselective synthesis approach
  • Employed triple Grignard addition
  • Implemented a hydroalkoxylation sequence
  • Started from coumarin-fused bridged ketones
  • Successfully synthesized highly functionalized dioxaadamantanes
  • Achieved high diastereoselectivity in the synthesis process
  • Demonstrated the utility of the synthesis in producing frameworks found in pharmaceuticals

Abstract

Highly functionalized adamantanes and heteroadamantanes are present as privileged structures in pharmaceuticals and are are also prevalent in bioactive natural products. However, efficient synthetic methods for these frameworks remain underdeveloped....

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6996a869ecb39a600b3ef1fehttps://doi.org/10.1039/d5qo01594d
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