Protocol of a comparative multicentric non inferiority clinical trial of WHO MBMDT with a new monthly chemotherapy regimen containing rifampicin, moxifloxacin and clarithromycin (RMC) on multibacillary patients from India

Joydeepa Darlong; Samrun Nessa; Itu Singh; Utpal Sengupta; Reeta Devi; Kartikeyan Govindasamy; Neeta Maximus; Vandana Elkana; Anamika Haldar; Ann Miriam Jose; Sylvia Jayakumar

doi:10.1186/s13063-026-09544-3

February 17, 2026TrialsOpen Access

Protocol of a comparative multicentric non inferiority clinical trial of WHO MBMDT with a new monthly chemotherapy regimen containing rifampicin, moxifloxacin and clarithromycin (RMC) on multibacillary patients from India

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Key Points

This trial aims to evaluate the non-inferiority of a new chemotherapy regimen compared to WHO MBMDT in treating multibacillary patients.
Multicentric clinical trial design
Involvement of multibacillary patients from India
Administration of a new regimen containing rifampicin, moxifloxacin, and clarithromycin
Ethical approval obtained from The Leprosy Mission Trust's ethics committee
Registered at Clinical Trials Registry-India
Results will be submitted for publication in peer-reviewed journals
Specific outcomes and data will be disclosed upon publication

Implication

A comparative clinical trial assesses a new chemotherapy regimen in multibacillary patients, indicating potential treatment advancements.

Abstract

Results will be submitted for publication in peer-reviewed journals. Ethical approval has been obtained from The Leprosy Mission Trust India's ethics committee (TLMTI/EC/C-69). This study is registered at Clinical Trials Registry-India (CTRI) - CTRI/2024/03/064435.

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Cite This Study

Darlong et al. (2026) studied this question.

synapsesocial.com/papers/6996a879ecb39a600b3ef440 https://doi.org/10.1186/s13063-026-09544-3

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Protocol of a comparative multicentric non inferiority clinical trial of WHO MBMDT with a new monthly chemotherapy regimen containing rifampicin, moxifloxacin and clarithromycin (RMC) on multibacillary patients from India

Key Points

Implication

Abstract

Discussion

Cite This Study

Protocol of a comparative multicentric non inferiority clinical trial of WHO MBMDT with a new monthly chemotherapy regimen containing rifampicin, moxifloxacin and clarithromycin (RMC) on multibacillary patients from India

Key Points

Implication

Abstract

Discussion

Cite This Study

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