What question did this study set out to answer?

To compare the oncological safety of less invasive axillary staging procedures to axillary lymph node dissection in breast cancer patients who convert from clinically node-positive to node-negative after neoadjuvant chemotherapy.

February 19, 2026Clinical Cancer Research

Abstract GS2-01: More versus less invasive axillary surgical staging procedures in breast cancer patients converting from a clinically node-positive to a clinically node-negative stage through neoadjuvant chemotherapy - primary endpoint analysis of the international prospective multicenter AXSANA/EUBREAST 3(R)study

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To compare the oncological safety of less invasive axillary staging procedures to axillary lymph node dissection in breast cancer patients who convert from clinically node-positive to node-negative after neoadjuvant chemotherapy.
Conducted as an international multicenter cohort study
Included patients with clinically positive (cN+) breast cancer converting to negative (ycN0) after neoadjuvant chemotherapy
Primary endpoints were axillary recurrence-free survival, invasive breast cancer-specific survival, and quality of life
Among 2,632 patients analyzed, 69.6% underwent less invasive procedures like SLNB and TAD
3-year axillary recurrence-free survival was 99.2% after ALND and 98.8% after less invasive methods
Findings support the efficacy of less invasive procedures with low recurrence rates, similar to ALND

Authors

TKT. KühnUniversity Hospital Ulm MBM. Banys-PaluchowskiKlinik für Frauenheilkunde NDN. DitschUniversity of Augsburg

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Implication

Multicenter study compares less invasive staging procedures and shows low recurrence rates in breast cancer patients after chemotherapy.

Cite This Study

Kühn et al. (2026) studied this question.

synapsesocial.com/papers/6996a8a9ecb39a600b3ef8b2 https://doi.org/10.1158/1557-3265.sabcs25-gs2-01

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