Abstract PS1-04-22: Impact of lifestyle coaching on physical activity, mental wellbeing, and cancer wellbeing scores

Background: Lifestyle interventions are known to impact physical activity, mental wellbeing, and cancer recovery outcomes. This project evaluated the effectiveness of a lifestyle medicine coaching program over 12 weeks for overweight and obese breast cancer survivors on follow up across three domains: physical activity (Exercise Vital Sign - EVS), mental wellbeing (Warwick-Edinburgh Mental Wellbeing Scale - WEMWBS), and cancer wellbeing (FACT-G7 scores). Methods: Fifteen participants were assessed pre- and post lifestyle medicine program of education and patient led goal-based coaching for healthy behaviour change led by a lifestyle medicine physician, nutritionist, cancer exercise specialist and yoga teacher. Exercise minutes per week, mental wellbeing scores, and cancer wellbeing scores were collected and analysed using paired t-tests and Wilcoxon Signed-Rank Tests. Results: Significant improvements were observed across all three outcome areas. Weekly exercise minutes increased from a mean of 75.2 to 201.0 (t (14) = -5.81, p < .001, Cohen’s d = 1.5). Mental wellbeing scores improved from a mean of 45.0 to 53.0 (p < .05), with 86% of participants showing a meaningful positive change. Cancer-related wellbeing scores improved from 14.3 to 20.5 (t (14) = -3.266, p = .006). The proportion of participants with low mental wellbeing reduced from 43% to 11% post-intervention, while those reporting high wellbeing increased from 7% to 16%. Conclusion: The lifestyle coaching program produced statistically significant and clinically meaningful improvements in physical activity, mental wellbeing, and cancer-related health outcomes. These findings support the integration of holistic, behaviour-based coaching interventions into health promotion and cancer survivorship care pathways. Citation Format: Z. Wasim, N. Goyal, A. Konstantis, S. Patel. Impact of lifestyle coaching on physical activity, mental wellbeing, and cancer wellbeing scores [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS1-04-22.