The present study aims to formulate and evaluate a wound healing microemulsion-based ointment using Jasminum sambac leaves and Terminalia chebula fruits, both known for their traditional medicinal applications. The plant materials were collected, authenticated, shade-dried, and extracted to obtain phytoconstituent-rich extracts with proven antimicrobial, antioxidant, and anti-inflammatory properties. Jasminum sambac leaves extract and Terminalia chebula extract was prepared by using Soxhlet extraction. microemulsion system was developed using suitable oils, surfactants, and co-surfactants to enhance the solubility, penetration, and therapeutic activity of the combined herbal extracts. The microemulsion was further incorporated into an ointment base and evaluated for physicochemical parameters such as appearance, pH, viscosity, spreadability, and stability. The results indicated that the formulated microemulsion-based ointment exhibited acceptable physicochemical characteristics, good stability, and uniform drug distribution. The formulation demonstrated significant antimicrobial activity and enhanced wound healing potential compared to conventional formulations. The synergistic action of Jasminum sambac and Terminalia chebula extracts, along with the advantages of the microemulsion delivery system, contributed to improved therapeutic efficacy and demonstrated that the combined extract microemulsion-based ointment exhibited good stability, enhanced skin permeation, strong antimicrobial effects, and significant wound healing activity compared to conventional formulations. Overall, the synergy of Jasminum sambac and Terminalia chebula in a microemulsion system shows promise as a natural and effective wound healing formulation.
Mumtaj Begum A.*1, Sandhiya R.2, Pradeep Kumar P.3, Tamilselvam K.4, Naresh S.5, Nandhu S.6 (Tue,) studied this question.