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February 19, 2026Chemical Communications0 citations

Diastereoselective intramolecular O-allylation with alkynes using Palladium/Brønsted acid combined catalysis: Access to substituted chiral oxazolidines

BKBhavya KhaitanSPSangram Keshari PandaSGShikha Gandhi

Key Points

  • The aim is to develop an efficient method for diastereoselective intramolecular allylation of O-nucleophiles.
  • Utilized palladium as a catalyst
  • Employed Brønsted acid as a co-catalyst
  • Focused on N-tethered alkynes for the reactions
  • Performed atom-economic pathway synthesis
  • Achieved high diastereoselectivity in the reactions
  • Successfully synthesized substituted chiral oxazolidines
  • Demonstrated the efficacy of the combined catalysis approach

Abstract

A Pd-catalyzed highly diastereoselective intramolecular allylation of O-nucleophiles with N-tethered alkynes has been developed. The reaction utilizes Brønsted acid as a co-catalyst and provides a completely atom-economic pathway to access...

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Cite This Study

Khaitan et al. (2026) studied this question.

synapsesocial.com/papers/6996a8d4ecb39a600b3f0014https://doi.org/10.1039/d6cc00614k
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