Diastereoselective intramolecular O-allylation with alkynes using Palladium/Brønsted acid combined catalysis: Access to substituted chiral oxazolidines

Bhavya Khaitan; Sangram Keshari Panda; Shikha Gandhi

doi:10.1039/d6cc00614k

January 1, 2026Chemical Communications

Diastereoselective intramolecular O-allylation with alkynes using Palladium/Brønsted acid combined catalysis: Access to substituted chiral oxazolidines

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Key Points

The aim is to develop an efficient method for diastereoselective intramolecular allylation of O-nucleophiles.
Utilized palladium as a catalyst
Employed Brønsted acid as a co-catalyst
Focused on N-tethered alkynes for the reactions
Performed atom-economic pathway synthesis
Achieved high diastereoselectivity in the reactions
Successfully synthesized substituted chiral oxazolidines
Demonstrated the efficacy of the combined catalysis approach

Implication

Demonstrates diastereoselective O-allylation in alkynes, suggesting a novel pathway for synthesizing chiral compounds.

Abstract

A Pd-catalyzed highly diastereoselective intramolecular allylation of O-nucleophiles with N-tethered alkynes has been developed. The reaction utilizes Brønsted acid as a co-catalyst and provides a completely atom-economic pathway to access...

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Cite This Study

Khaitan et al. (2026) studied this question.

synapsesocial.com/papers/6996a8d4ecb39a600b3f0014 https://doi.org/10.1039/d6cc00614k

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Diastereoselective intramolecular O-allylation with alkynes using Palladium/Brønsted acid combined catalysis: Access to substituted chiral oxazolidines

Key Points

Implication

Abstract

Discussion

Cite This Study

Diastereoselective intramolecular O-allylation with alkynes using Palladium/Brønsted acid combined catalysis: Access to substituted chiral oxazolidines

Key Points

Implication

Abstract

Discussion

Cite This Study

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