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Combination therapy improves efficacy in tumors through immunosuppression reduction and enhanced checkpoint blockade.
Heating Cold Breast Cancers Effectively This cover art reimagines Investiture of the Gods. The Lady Shiji represents mTOR-driven immune evasion in triple-negative breast cancer (Skull Mountain). Nezha, representing a gold nanocomposite, strikes with his Spear (mTOR inhibitor) and Universe Ring (photothermal therapy), while Taiyi Zhenren (anti-PD-1) empowers T cells to attack Skull Mountain (tumor). This illustrates the strategy by Jing Jing, Xiaowei Liu, and co-workers to reverse immunosuppression and treat cold tumors. More details can be found in the Research Article (DOI: 10.1002/advs.202513711 ).
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Zhao et al. (2026) studied this question.
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