Defining response-adapted surgery after neoadjuvant systemic therapy in sinonasal squamous cell carcinoma

The proposed system introduces the first response-adapted surgery classification to encompass patients with locoregionally advanced sinonasal SCC treated with neoadjuvant therapy prior to definitive surgical resection. By extending standardized terminology, this framework enhances communication within multidisciplinary teams, enables meaningful comparisons across published studies, and supports consistency in developing clinical trial endpoints seeking to balancing oncologic control and functional preservation.