Synthesis of various DNA hybrid nanocomposites and investigation of peroxidase mimic activity

Purpose: The aim of this study is to synthesize hybrid nanocomposites from various DNA sequences and to investigate their peroxidase mimic activities. Method: The DNA sequences were used as the organic component and the copper (II) ions were used as the inorganic component for the synthesis. The effect of different synthesis conditions (pH and concentration) on morphology was investigated using a scanning electron microscope. Additionally, the peroxidase mimic activity of nanocomposites was examined. Findings: DNA sequences coded as C20, C20A and C20AA were used at various concentrations within three synthesis environments with different pH levels. This resulted in the formation of flower-like hybrid nanocomposite structures. These structures also exhibited effective peroxidase mimic activity. Conclusion: Various DNA hybrid nanocomposites can be synthesised successfully. These nanocomposites could be used in DNA-related drug delivery systems.